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| Status |
Public on Feb 16, 2013 |
| Title |
Smooth muscle specific deletion of N-deacetylase-N-sulfotransferase 1 (Ndst1) results in increased arterial elasticity in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The hypothesis tested was that loss of Ndst1 in smooth muscle would lead to significant changes in gene expression and alter functional properties in large and small vessels. The increase in aortic elasticity was increased in mice lacking Ndst1 was associated with significant changes in genes that modify mechano-sensing, contractility and elasticity.
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| Overall design |
Total RNA extracted from aorta from smooth muscle specific Ndst1 deficient mice (SM22αcre+Ndst1-/-) was compared to aorta from wild type (WT, SM22αcre-Ndst1wt/wt ) control mice.
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| Contributor(s) |
Adhikari N, Hall JL, Staggs R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 15, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Neeta Adhikari |
| E-mail(s) |
adhik001@umn.edu
|
| Organization name |
University of Minnesota
|
| Department |
Lillehei Heart Institute
|
| Street address |
312 Church Street SE
|
| City |
Minneapolis |
| State/province |
Minnesota |
| ZIP/Postal code |
55406 |
| Country |
USA |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA189509 |
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