|
| Status |
Public on Sep 01, 2013 |
| Title |
DOCK8 is critical for the survival and function of NKT cells [DOCK8_CPM_NKT] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of DOCK8 deficient animals revealed a key role for this protein the survival and maintenance of natural killer T cells. This work lead to the identification of genes regulated by the guanine exchange factor, DOCK8.
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| |
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| Overall design |
Total RNA was extracted from 3 biological replicates of thymic, DOCK8 deficient NKT cells and compared using an Illumina microarray to WT NKT cells.
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| |
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| Contributor(s) |
Crawford G, Gileadi U, Lockstone HE, Cornall RJ |
| Citation(s) |
23929855 |
| Submission date |
Mar 04, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Richard Cornall |
| E-mail(s) |
richard.cornall@ndm.ox.ac.uk
|
| Organization name |
University of Oxford
|
| Department |
Centre of Cellular and Molecular Physiology
|
| Street address |
Roosevelt Drive
|
| City |
Oxford |
| ZIP/Postal code |
OX37BN |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (6)
|
| GSM1092001 |
DOCK8 knockout, thymic, NK1.1+ NKT cells replicate1 |
| GSM1092002 |
DOCK8 knockout, thymic, NK1.1+ NKT cells replicate2 |
| GSM1092003 |
DOCK8 knockout, thymic, NK1.1+ NKT cells replicate3 |
| GSM1092004 |
Wildtype, thymic, NK1.1+ NKT cells replicate1 |
| GSM1092005 |
Wildtype, thymic, NK1.1+ NKT cells replicate2 |
| GSM1092006 |
Wildtype, thymic, NK1.1+ NKT cells replicate3 |
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| This SubSeries is part of SuperSeries: |
| GSE44816 |
DOCK8 is critical for the survival and function of NKT cells |
|
| Relations |
| BioProject |
PRJNA191949 |
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