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| Status |
Public on Apr 04, 2013 |
| Title |
Expression Data from 24 orthotopic tumors grown in the pancreas of mice +/- MEK inhibitor PD0325901 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.
We used microarrays to find gene expression patterns associated with drug response and also identified genes regulated by the MAP kinase pathway
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| Overall design |
6 pancreatic cell lines were injected into the pancreas of nude mice and treated either with vehicle control or PD0325901 for 12 plus 12 hours.
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| Contributor(s) |
Gysin S, Paquette J, McMahon M |
| Citation(s) |
22833572 |
| Submission date |
Apr 03, 2013 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Stephan Christoph Gysin |
| E-mail(s) |
sgysin@cc.ucsf.edu
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| Organization name |
UCSF
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| Department |
HDFCCC
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| Lab |
McCormick
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| Street address |
1450 3rd Street
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| City |
San Francisco |
| State/province |
California |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (24)
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| GSM1113815 |
PL45 #1, PD0325901 |
| GSM1113816 |
MIAPaCa-2 #4, PD0325901 |
| GSM1113817 |
MIAPaCa-2, #5, PD0325901 |
| GSM1113818 |
PL45, #2, vehicle |
| GSM1113819 |
PL45, #3, PD0325901 |
| GSM1113820 |
Panc-2.12, #1, vehicle |
| GSM1113821 |
Panc-2.12, #2, vehicle |
| GSM1113822 |
Panc-2.12, #3, vehicle |
| GSM1113823 |
Panc-2.12, #4, PD0325901 |
| GSM1113824 |
Panc-2.12, #5, PD0325901 |
| GSM1113825 |
Panc-2.12, #6, PD0325901 |
| GSM1113826 |
Hs766T, #1, vehicle |
| GSM1113827 |
Hs766T, #2, PD0325901 |
| GSM1113828 |
SU86.86, #1, vehicle |
| GSM1113829 |
SU86.86, #2, vehicle |
| GSM1113830 |
SU86.86, #3, PD0325901 |
| GSM1113831 |
SU86.86, #4, PD0325901 |
| GSM1113832 |
L3.6pl, #1, PD0325901 |
| GSM1113833 |
L3.6pl, #2, PD0325901 |
| GSM1113834 |
L3.6pl, #3, vehicle |
| GSM1113835 |
L3.6pl, #4, vehicle |
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| This SubSeries is part of SuperSeries: |
| GSE45765 |
Expression Data from pancreatic cancer cell lines and orthotopic tumors grown with and without MEK inhibitor |
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| Relations |
| BioProject |
PRJNA196178 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE45758_RAW.tar |
57.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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