|
| Status |
Public on Aug 12, 2014 |
| Title |
Genome-wide DNA methylation aberrations in human atherosclerosis (sequencing) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it functions as effector for environmental impacts, including dietary and life-style, similarly to risk factors for cardiovascular diseases. We addressed this issue by performing whole-genome shotgun bisulfite sequencing and high-resolution DNAmethylation array analysis of healthy and diseased donor-matched atherosclerotic DNA methylomes.
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| |
|
| Overall design |
Sequencing of bisulfite converted DNA and array based analysis of atherosclerotic lesions and normal carotid tissue.
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| |
|
| Contributor(s) |
Esteller M, Heyn H |
| Citation(s) |
25091541, 25881171, 35657981 |
| Submission date |
Apr 23, 2013 |
| Last update date |
Jun 23, 2022 |
| Contact name |
Manel Esteller |
| Organization name |
IDIBELL
|
| Department |
PEBC
|
| Lab |
Cancer Epigenetics
|
| Street address |
Hospital Duran i Reynals Av. Gran Via s/n km, 2.7
|
| City |
L'Hospitalet de Llobregat |
| State/province |
Barcelona |
| ZIP/Postal code |
08908 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE46401 |
Genome-wide DNA methylation aberrations in human atherosclerosis |
|
| Relations |
| BioProject |
PRJNA198740 |
| SRA |
SRP021479 |
