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Series GSE47457 Query DataSets for GSE47457
Status Public on Aug 31, 2023
Title Gene expression in nucleus accumbens tissue of Foxp2 heterozygous mice (S321X/+) and wild-type littermates (WT) following single cocaine or saline injection
Organism Mus musculus
Experiment type Expression profiling by array
Summary Foxp2 heterozygous mice and wildtype mice were injected with cocaine or saline, 1h post-injection nucleus acumbens RNA was extracted and analysed
We have tested a potential role for the transcription factor Foxp2 in dopamine signaling and reward associated synaptic plasticity and behavior. We found that Foxp2 is acutely downregulated in reward associated circuits in the nucleus accumbens following a single injection of cocaine. In Foxp2 heterozygous mutant mice, loss of transcriptional suppression by Foxp2 causes an increased constitutive expression of dopamine signaling related genes which corresponds with impairments in synaptic plasticity and reward associated behaviors.
 
Overall design Nucleus accumbens tissue was extracted 1 hour after injection (i.p.) of either saline or cocaine (15mg/kg). mRNA microarrays (Illumina MouseWG-6 v2) were used to analyzed gene expression in biological replicates (6 for WT cocain, 6 for WT saline, 5 for HET (S321X/+) saline, 6 for HET (S321X/+) cocain).
 
Contributor(s) Mombereau C, Ghosh T, Groszer M
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Submission date May 29, 2013
Last update date Aug 31, 2023
Contact name Matthias Groszer
Organization name INSERM U839
Department Developmental Neuroscience
Street address 17, rue du Fer à Moulin
City Paris
ZIP/Postal code 75005
Country France
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (23)
GSM1149916 heterozygote saline biological replicate1
GSM1149917 wildtype saline biological replicate 1
GSM1149918 heterozygote cocaine biological replicate 1
Relations
BioProject PRJNA205637

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47457_RAW.tar 15.8 Mb (http)(custom) TAR
GSE47457_non-normalized.txt.gz 6.2 Mb (ftp)(http) TXT
Processed data included within Sample table
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