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| Status |
Public on Jul 20, 2016 |
| Title |
RNA-Seq analysis of primary AML specimens exposed to AhR modulating agents |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of the study was to identify genes that are directly or indirectly coregulated by the AhR pathway in primary human AML cells. Patient AML cells were treated for 16 hours with the two indirubin derivatives 6-bromoindirubin-3'oxime (BIO), 1-Methyl-6-bromoindirubin-3'oxime (MeBIO), the AHR-antagonist SR1 (StemReginin1), combinations of BIO+SR1 and MeBIO+SR1 or DMSO alone at indicated concentrations prior to RNA extraction for sequencing.
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| |
|
| Overall design |
RNA-Seq performed on 5 primary AML samples fresh (t0) and after exposure to AhR-agonists (2), -antagonist (1), and DMSO
Contributor: Leucegene Project, IRIC
|
| |
|
| Contributor(s) |
Pabst C, Sauvageau G, Hebert J |
| Citation(s) |
26834243 |
| Submission date |
Jul 12, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Guy Sauvageau |
| Organization name |
Institute for Research in Immunology and Cancer
|
| Street address |
2950, Chemin de Polytechnique
|
| City |
Montreal |
| State/province |
QC |
| ZIP/Postal code |
H3T 1J4 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (32)
|
|
| Relations |
| BioProject |
PRJNA214460 |
| SRA |
SRP028567 |
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