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| Status |
Public on Jul 29, 2013 |
| Title |
Human hepatic stellate cell line LX-2 activated under acidic culture condition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We found that the number of tumor-infiltrating myofibroblasts was positively correlated to tumor acidification status in hepatocellular carcinoma (HCC). Hepatic stellate cells (HSCs), the predominant precursors of liver myofibroblasts, were activated and transdifferentiated into myofibroblasts under acidic culture condition.
To identify the molecular phenotype of LX-2 cells in acidic culture conditions, we further conducted a gene expression profile analysis.
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| Overall design |
LX-2 cells cultured in pH 7.2 or pH 6.2 medium separately for six days was used in gene expression microarray analysis.
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| Contributor(s) |
Song J, Qin W |
| Citation missing |
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| Submission date |
Jul 29, 2013 |
| Last update date |
Oct 11, 2016 |
| Contact name |
Wenxin Qin |
| E-mail(s) |
wxqin@sjtu.edu.cn
|
| Phone |
+86-21-64436581
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| Organization name |
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
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| Lab |
State Key Laboratory of Oncogenes and Related Genes
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| Street address |
No. 25/Ln 2200 Xie-Tu Road
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA213578 |
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