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Series GSE49832 Query DataSets for GSE49832
Status Public on Apr 17, 2014
Title Hes6 drives a critical AR transcriptional program to induce castration resistant prostate cancer through activation of an E2F1-mediated cell cycle network
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Castrate-resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other factors such as c-Myc and the E2F family also play a role in later stage disease. Here we show that Hes6 is up-regulated in aggressive human prostate cancer and drives castration-resistant tumour growth in the absence of ligand binding by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for other transcription factors including E2F1. In the clinical setting, we have uncovered a Hes6-associated signature that predicts poor outcome in prostate cancer, which can be pharmacologically targeted with restoration of sensitivity to castration.
 
Overall design AR and E2F1 ChIPseq from multiple simultaneous LNCaP cell replicates with and without bicalutamide
 
Contributor(s) Ramos-Montoya A, Lamb A, Russell R, Carroll T
Citation(s) 24737870
Submission date Aug 13, 2013
Last update date May 15, 2019
Contact name Chandra Chilamakuri
E-mail(s) datasubmissions@cruk.cam.ac.uk
Organization name Cancer Research UK Cambridge Institute
Street address Robinson Way
City Cambridge
ZIP/Postal code CB2 0RE
Country United Kingdom
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (38)
GSM1207880 ID-LNCAP-LM-HES6-BICALUTAMIDE-INPUT-D26_r1
GSM1207881 IF-LNCAP-LM-HES6-BICALUTAMIDE-INPUT-D2_r1
GSM1207882 IG-LNCAP-LM-EV-VEHICLE-INPUT-D2_r1
This SubSeries is part of SuperSeries:
GSE36526 Hes6 drives a network with therapeutic potential in castrate-resistant prostate cancer
Relations
BioProject PRJNA215063
SRA SRP028816

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49832_RAW.tar 8.5 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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