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| Status |
Public on Jul 24, 2001 |
| Title |
Global profile of germline gene expression in C. elegans |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
This research has been described more fully in Reinke V et al.(2000) Mol Cell 6:605-16
Keywords: other
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| Contributor(s) |
Reinke V, Smith HE, Nance J, Wang J, Van Doren C, Begley R, Jones SJ, Davis EB, Scherer S, Ward S, Kim SK |
| Citation(s) |
11030340 |
| Submission date |
Jul 24, 2001 |
| Last update date |
Feb 23, 2012 |
| Organization |
Stanford Microarray Database (SMD) |
| E-mail(s) |
array@genome.stanford.edu
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| Phone |
650-498-6012
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| URL |
http://genome-www5.stanford.edu/
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| Department |
Stanford University, School of Medicine
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| Street address |
300 Pasteur Drive
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (1) |
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| Samples (34)
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| GSM436 |
fem-3(q23) (red, channel 2) vs. fem-1(hc17) (green, channel 1) |
| GSM437 |
fem-3(q23) (red, channel 2) vs. fem-1(hc17) (green, channel 1)- repeat #1 |
| GSM438 |
vjr N2 mixed control (red, channel 2) vs N2-3 T4 (green, channel 1) |
| GSM439 |
vjr N2 mixed control (red, channel 2) vs bn2-1 T5 (green, channel 1) |
| GSM440 |
vjr N2 mixed control (red, channel 2) vs bn2-3 T4 (green, channel 1) |
| GSM441 |
vjr N2 mixed control (red, channel 2) vs N2-2 T4 (green, channel 1) |
| GSM442 |
vjr N2 mixed control (red, channel 2) vs N2-4 T4 (green, channel 1) |
| GSM443 |
vjr N2 mixed control (red, channel 2) vs bn2-2 T4 (green, channel 1) |
| GSM444 |
vjr N2 mixed control (red, channel 2) vs bn2-4 T4 (green, channel 1) |
| GSM445 |
vjr N2 mixed control (red, channel 2) vs N2-2 T2 (green, channel 1) |
| GSM446 |
vjr mixed control (red, channel 2) vs N2-2 T3 (green, channel 1) |
| GSM447 |
vjr mixed contol (red, channel 2) vs bn2-2 T2 (green, channel 1) |
| GSM448 |
vjr mixed control (red, channel 2) vs bn2-2 T3 (green, channel 1) |
| GSM449 |
vjr N2 mixed control (red, channel 2) vs N2-4 T2 (green, channel 1) |
| GSM450 |
vjr mixed control (red, channel 2) vs N2-4 T3 (green, channel 1) |
| GSM451 |
vjr mixed contol (red, channel 2) vs bn2-4 T2 (green, channel 1) |
| GSM452 |
vjr mixed control (red, channel 2) vs bn2-4 T3 (green, channel 1) |
| GSM453 |
REF-vjr (red, channel 2) vs N2 #3 L3 (green, channel 1) |
| GSM454 |
REF-vjr (red, channel 2) vs N2 #3 L4 (green, channel 1) |
| GSM455 |
REF-vjr (red, channel 2) vs bn2 #3 L3 (green, channel 1) |
| GSM456 |
REF-vjr (red, channel 2) vs bn2 #3 L4 (green, channel 1) |
| GSM457 |
REF-vjr (red, channel 2) vs N2 #1 L4 (green, channel 1) |
| GSM458 |
REF-vjr (red, channel 2) vs bn2 #1 L4 (green, channel 1) |
| GSM459 |
REF-vjr (red, channel 2) vs bn2 #1 L3 (green, channel 1) |
| GSM460 |
REF-vjr (red, channel 2) vs N2 #1 L2 (green, channel 1) |
| GSM461 |
REF-vjr (red, channel 2) vs N2 #2 L2 (green, channel 1) |
| GSM462 |
REF-vjr (red, channel 2) vs N2 #3 L2 (green, channel 1) |
| GSM463 |
REF-vjr (red, channel 2) vs glp-4 #1 L2 (green, channel1) |
| GSM464 |
REF-vjr (red, channel 2) vs glp-4 #2 and #4 L2 (green, channel 1) |
| GSM465 |
REF-vjr (red, channel 2) vs glp-4 #3 L2 (green, channel 1) |
| GSM466 |
REF-vjr (red, channel 2) vs N2 #1 L3 (green, channel 1) |
| GSM467 |
fem3 #4 (red, channel 2) vs. fem1 #4 (green, channel 1) |
| GSM468 |
fem3 #5 (red, channel 2) vs. fem1 #5 (green, channel 1) |
| GSM469 |
fem3 #1 (red, channel 2) fem1 #1 (green, channel 1) |
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| Relations |
| BioProject |
PRJNA85207 |
| Supplementary data files not provided |
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