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| Status |
Public on Aug 24, 2007 |
| Title |
Effect of INF-gamma and IL1-beta on thyroid cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Normal primary thyroid cells were incubated with vehicle, 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. RNA expression was analyzed using Affymetrix HG_U133A arrays for 3 of the thyroids, and HG_U133A_2.0 (small version of HG_U133A) arrays for 2 of the thyroids.
Keywords: cytokine treatments
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| Overall design |
Normal primary thyroid cells were incubated with vehicle, 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. One array was hybridized per sample (20 samples).
The probe-set intensities with accompanying statistical analysis (2-way ANOVA) and the associated README file are included as Supplementary files.
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| Contributor(s) |
Baker JR, Wang SH, Van Antwerp M, Kuick R, Gauger PG, Doherty GM |
| Citation(s) |
17640998 |
| Submission date |
Jun 12, 2006 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Rork Kuick |
| E-mail(s) |
rork@umich.edu
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| Phone |
734-936-9241
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| Organization name |
University of Michigan
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| Street address |
University of Michigan, SPH II, 1415 Washington Heights, Room M2533
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| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109-2029 |
| Country |
USA |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (20)
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| GSM113926 |
Normal primary thyroid cells, thyroid #1, control treatment |
| GSM113927 |
Normal primary thyroid cells, thyroid #1, IFN-gamma treatment |
| GSM113928 |
Normal primary thyroid cells, thyroid #1, IL1-beta treatment |
| GSM113929 |
Normal primary thyroid cells, thyroid #1, combined IFN-gamma and IL1-beta treatment |
| GSM113930 |
Normal primary thyroid cells, thyroid #2, control treatment |
| GSM113931 |
Normal primary thyroid cells, thyroid #2, IFN-gamma treatment |
| GSM113932 |
Normal primary thyroid cells, thyroid #2, IL1-beta treatment |
| GSM113933 |
Normal primary thyroid cells, thyroid #2, combined IFN-gamma and IL1-beta treatment |
| GSM113934 |
Normal primary thyroid cells, thyroid #3, control treatment |
| GSM113935 |
Normal primary thyroid cells, thyroid #3, IFN-gamma treatment |
| GSM113936 |
Normal primary thyroid cells, thyroid #3, IL1-beta treatment |
| GSM113937 |
Normal primary thyroid cells, thyroid #3, combined IFN-gamma and IL1-beta treatment |
| GSM113938 |
Normal primary thyroid cells, thyroid #4, control treatment |
| GSM113939 |
Normal primary thyroid cells, thyroid #4, IFN-gamma treatment |
| GSM113940 |
Normal primary thyroid cells, thyroid #4, IL1-beta treatment |
| GSM113941 |
Normal primary thyroid cells, thyroid #4, combined IFN-gamma and IL1-beta treatment |
| GSM113942 |
Normal primary thyroid cells, thyroid #5, control treatment |
| GSM113943 |
Normal primary thyroid cells, thyroid #5, IFN-gamma treatment |
| GSM113944 |
Normal primary thyroid cells, thyroid #5, IL1-beta treatment |
| GSM113945 |
Normal primary thyroid cells, thyroid #5, combined IFN-gamma and IL1-beta treatment |
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| Relations |
| BioProject |
PRJNA96695 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE5054_IFNG_IL1B.xls |
21.5 Mb |
(ftp)(http) |
XLS |
| GSE5054_RAW.tar |
67.7 Mb |
(http)(custom) |
TAR (of CEL) |
| GSE5054_README.txt |
1.9 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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