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| Status |
Public on Aug 08, 2014 |
| Title |
Comparison of gene expression in wild-type Drosophila testes with tbrd-1 mutant testes |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression is tightly linked to histone acetylation on lysine residues that can be recognized by bromodomains. The testis-specific bromodomain protein tBRD-1 is essential for male fertility and might act as a co-factor of testis-specifc TAFs. Here, we perform microarray analyses and demonstrate that tBRD-1 selectively controls gene expression in male germ cells
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| Overall design |
Testes were dissected from 0-2 day old Drosophila males. The wild-type control sample was w1118. The tbrd-1 mutant is described in Leser et al., 2012 (Leser K, Awe S, Barckmann B, Renkawitz-Pohl R, Rathke C. 2012. The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility. Biology Open 1: 597-606)
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| Contributor(s) |
Rathke C, Bartkuhn M |
| Citation(s) |
25251222 |
| Submission date |
Nov 19, 2013 |
| Last update date |
May 04, 2018 |
| Contact name |
Marek Bartkuhn |
| E-mail(s) |
marek.bartkuhn@gen.bio.uni-giessen.de
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| Organization name |
Justus-Liebig-University Giessen
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| Department |
Biomedical Informatics and Systems Medicine
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| Street address |
Aulweg 132
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| City |
Giessen |
| State/province |
Hessen |
| ZIP/Postal code |
35392 |
| Country |
Germany |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (10)
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| GSM1268012 |
testis_tbrd-1-mutant_biological replicate_1 |
| GSM1268013 |
testis_tbrd-1-mutant_biological replicate_2 |
| GSM1268014 |
testis_tbrd-1-mutant_biological replicate_3 |
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| Relations |
| BioProject |
PRJNA229150 |
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