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| Status |
Public on Mar 01, 2014 |
| Title |
WT and FcgKO peritoneal MF response to IL4 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. Using functional and gene expression analysis we describe the role for the tonic signaling through Fcg-chain, the major ITAM-module of the innate immune system, in modifying cytokine responses in MF.
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| Overall design |
Peritoneal MF were left unstimulated or were stimulated in duplicates for 6 hrs with IL4. cDNA was analyzed using 8-sample Mouse Ref-8 v2.0 Illumina array. Expressed genes were defined as those with p<0.05, and their relative expression values were calculated using average of two WT unstimulated samples as calibrator.
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| Contributor(s) |
Ruslan M |
| Citation(s) |
24608040 |
| Submission date |
Feb 10, 2014 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Ruslan Medzhitov |
| Organization name |
Yale University
|
| Department |
Immunobiology
|
| Street address |
PO Box 208011 300 Cedar Street TAC S660
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06520 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE54824 |
A role for the ITAM signaling module in specifying cytokine receptor functions |
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| Relations |
| BioProject |
PRJNA237758 |
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