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| Status |
Public on Sep 01, 2006 |
| Title |
Androgen-starved LNCaP cells treated with celastrol and androgen, androgen alone, or vehicle alone for 24h |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
celastrol is a natural product that affects LNCaP androgen-signalling by 24h
We used microarrays to detail the androgen-responsive program of gene expression affected by celastrol treatment at 24h
Keywords: drug treatment
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| Overall design |
LNCaP cells were grown to 50% confluency and deprived of androgen, and subsequently treated with celastrol plus androgen, androgen alone, or vehicle alone for 24h prior to direct Trizol lysis and RNA isolation
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| Contributor(s) |
Hieronymus H, Golub TR |
| Citation(s) |
17010675 |
| Submission date |
Aug 11, 2006 |
| Last update date |
Jan 24, 2017 |
| Contact name |
Haley Hieronymus |
| E-mail(s) |
haley@broad.mit.edu
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| URL |
http://www.broad.mit.edu/cgi-bin/cancer/publications/pub_menu.cgi
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| Organization name |
Broad Institute of Harvard and MIT
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| Street address |
7 Cambridge Center
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| City |
CAMBRIDGE |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
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| Platforms (1) |
| GPL3921 |
[HT_HG-U133A] Affymetrix HT Human Genome U133A Array |
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| Samples (9)
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| GSM127027 |
LNCaP cells treated with 1nM R1881 and 1.25uM celastrol for 24h, biol repl 1 |
| GSM127028 |
LNCaP cells treated with 1nM R1881 and 1.25uM celastrol for 24h, biol repl 2 |
| GSM127029 |
LNCaP cells treated with 1nM R1881 and 1.25uM celastrol for 24h, biol repl 3 |
| GSM127030 |
Androgen-starved LNCaP cells, treated with ethanol and DMSO for 24h, biol repl 1 (celastrol control) |
| GSM127031 |
Androgen-starved LNCaP cells, treated with ethanol and DMSO for 24h, biol repl 2 (celastrol control) |
| GSM127032 |
Androgen-starved LNCaP cells, treated with ethanol and DMSO for 24h, biol repl 3 (celastrol control) |
| GSM127033 |
Androgen-starved LNCaP cells, treated with 1nM R1881 and DMSO for 6h, biol repl 1 (celastrol) |
| GSM127034 |
Androgen-starved LNCaP cells, treated with 1nM R1881 and DMSO for 6h, biol repl 2 (celastrol) |
| GSM127035 |
Androgen-starved LNCaP cells, treated with 1nM R1881 and DMSO for 6h, biol repl 3 (celastrol) |
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| Relations |
| BioProject |
PRJNA96159 |
| Supplementary data files not provided |
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