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| Status |
Public on Oct 15, 2014 |
| Title |
micro RNA-379 couples glucocorticoid hormones to metabolic dysfunction in diabesity |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
In metabolic control, GC signaling acts as a major counter-regulatory system against insulin action, and aberrantly elevated GC activity is tightly linked to major components of the so-called Metabolic Syndrome, including obesity, insulin resistance, hyperglycemia, and systemic dyslipidemia. Here we identify the hepatic induction of the conserved microRNA (miR)-379/410 genomic cluster as a key component of GC/GR-driven metabolic dysfunction in “diabesity”
Microarray data were utilized to screened for differentially regulated miRNAs between wt and db/db and between wt and GR Knockdown mice
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| Overall design |
For wt vs. db/db: mice were fasted for 24 hours and refed for 6 hours; For GR-dependent miRNAs: mice were treated with rAAV delivering either control or GR-directed miRNA for the knockdown of the GR specifically in the liver.
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| Contributor(s) |
de Guia RM, Rose AJ, Sommerfeld A, Seibert O, Strzoda D, Zota A, Feuchter Y, Krones-Herzig A, Sticht C, Gretz N, Dallinga-Thie G, Diederichs S, Klöting N, Blüher M, Diaz MB, Herzig S |
| Citation(s) |
25510864 |
| Submission date |
Feb 21, 2014 |
| Last update date |
May 02, 2017 |
| Contact name |
Carsten Sticht |
| Organization name |
University Heidelberg
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| Department |
ZMF
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| Street address |
Theodor-Kutzer-Ufer
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| City |
Mannheim |
| ZIP/Postal code |
68169 |
| Country |
Germany |
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| Platforms (1) |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA238989 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE55245_RAW.tar |
9.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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