|
| Status |
Public on Jul 18, 2014 |
| Title |
Markers of persistent multifunctional memory CD4+ T cells in latent TB infection |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In latent tuberculosis infection (LTBI) spread of the bacteria is contained by a persistent immune response, which includes CD4+ T cells as important contributors. Here we show that TB-specific CD4+ T cells have a characteristic chemokine expression signature (CXCR3+CCR6+CCR4-; Th* cells), and that the overall number of Th* cells is significantly increased in LTBI donors. We have comprehensively characterized the transcriptional signature of Th* cells and find significant differences to conventional Th1, Th17 and Th2 cells, but no major changes between healthy and LTBI donors. Th* cells display linage-specific signatures of both Th1 and Th17 cells, but also have a unique gene expression program including genes associated with susceptibility to TB, enhanced T cell activation, enhanced cell survival, and induction of a cytotoxic program akin to CTL cells. Overall, the gene expression signature of Th* reveals characteristics of cells important in controlling latent infections.
|
| |
|
| Overall design |
Examination of gene expression in 5 human cell types in healthy and Latent TB infected individuals .
The 'Differentially_expressed_genes.xlsx' contains genes that are differentially expressed in pair-wise comparisons of different cell types and disease groups. The data format/content description is provided in the 'readme.txt'
|
| |
|
| Contributor(s) |
Arlehamn CL, Seumois G, Peters B, Gerasimova A, Vijayanand P |
| Citation(s) |
25092889 |
| Submission date |
Mar 25, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Anna Gerasimova |
| Organization name |
La Jolla Institute for Allergy and Immunology
|
| Street address |
9420 Athena Circle
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16558 |
AB 5500 Genetic Analyzer (Homo sapiens) |
|
| Samples (56)
|
|
| Relations |
| BioProject |
PRJNA242649 |
| SRA |
SRP040585 |
Less...
More...