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| Status |
Public on Feb 13, 2015 |
| Title |
A Methylation-Based Signature Predicts Survival In Hepatocellular Carcinoma Patient |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Epigenetic deregulation is a critical event in human malignancies. A number of DNA methylation markers are currently under evaluation as diagnostic and prognostic biomarkers for many cancers. However, its potential role in hepatocellular carcinoma (HCC) is under-explored. Aims: To develop a DNA methylation-based prognostic signature in surgically resected HCC
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| Overall design |
Tumors from 224 HCC resected patients, 10 normal Liver individuals and 9 Cirrhotic patients were analyzed. Methylome profiling was done with Illumina HumanMethylation450 (485,000 CpG, 96% of known CpG islands). We selected probes in CpG islands located in promoters, hypermethylated (B value higher than 50%) in at least 5% of the tumors and hypomethylated (B value lower than 33%) in more than 90% of normal liver.
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| Contributor(s) |
Portela A, Esteller M, Villanueva A, Llovet J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 08, 2014 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Manel Esteller |
| Organization name |
IDIBELL
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| Department |
PEBC
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| Lab |
Cancer Epigenetics
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| Street address |
Hospital Duran i Reynals Av. Gran Via s/n km, 2.7
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| City |
L'Hospitalet de Llobregat |
| State/province |
Barcelona |
| ZIP/Postal code |
08908 |
| Country |
Spain |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (243)
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| Relations |
| BioProject |
PRJNA244008 |
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