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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 01, 2006 |
| Title |
Expression data from mouse IRF6 null and wt skin |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Transcription factor paralogs may share a common role (e.g. Hox) in staged or overlapping expression in specific tissues. In other examples, members have distinct roles in a range of embryologic, differentiation or response pathways (e.g. Tbx, Pax). For the Interferon Regulatory Factor (IRF) family of transcription factors, mice deficient in Irf1, Irf2, Irf3, Irf4, Irf5, Irf7, Irf8 or Irf9, have defects in the immune response but display no embryologic abnormalities. Mice deficient for Irf6 have not been reported, but in humans, mutations in IRF6 cause two Mendelian orofacial clefting syndrome, and genetic variation in IRF6 confers risk for isolated cleft lip and palate.
Mice deficient for Irf6 have abnormal skin, limb and craniofacial development. Histological and gene expression analyses indicate that the primary defect is in keratinocyte differentiation and proliferation. This study describes a novel role for an IRF family member in epidermal development.
Keywords: Comparison of tissue from two genotypes
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| Overall design |
Skin from E17.5 mice was removed and flash frozen for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Ingraham C, Kinoshita A, Kondo S, Yang B, Sajan S, Trout K, Malik M, Dunnwald M, Goudy S, Lovett M, Murray J, Schutte B |
| Citation(s) |
17041601 |
| Submission date |
Sep 08, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
David Michael Alvarado |
| E-mail(s) |
dmalvara@genetics.wustl.edu
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| Phone |
314-747-1063
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| Organization name |
Washington University in St. Louis
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| Department |
Genetics
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| Lab |
Michael Lovett
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| Street address |
4565 Scott Ave
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| City |
St. Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA97169 |
| Supplementary data files not provided |
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