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| Status |
Public on Dec 02, 2014 |
| Title |
Genome-wide analyses reveal DNA methylation in the central nucleus of the amygdala is linked to anxious temperament in young primates |
| Organism |
Macaca mulatta |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
We used reduced representation bisulfite sequencing to profiled 5-methylcytosine in the Ce of rhesus monkeys (N = 23) fully phenotyped for anxious temperament (AT) and identified 5,489 CpG sites (1,363 genes) with methylation levels predictive of individual differences in AT (FDR p-value < 0.05), including genes previously implicated in psychiatric-related disorders (e.g. GRIN1, GRM5, HTT, ADCYAP1, and SHANK3).
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| Overall design |
Used RRBS to profile the central nucleus of the amygdala of 23 monkeys and the resulting data analyzed using anxious temperament as a continuous trait using only age as a covariate.
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| Contributor(s) |
Alisch RS, Chopra P, Kalin NH |
| Citation(s) |
25411484 |
| Submission date |
Jun 20, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Reid Alisch |
| E-mail(s) |
alisch@wisc.edu
|
| Organization name |
University of Wisconsin School of Medicine
|
| Department |
Department of Psychiatry
|
| Lab |
Alisch lab
|
| Street address |
6001 Research Park Blvd.
|
| City |
Madison |
| State/province |
WI |
| ZIP/Postal code |
53719-1176 |
| Country |
USA |
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| Platforms (1) |
| GPL14954 |
Illumina HiSeq 2000 (Macaca mulatta) |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA253174 |
| SRA |
SRP043459 |
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