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| Status |
Public on Dec 03, 2014 |
| Title |
The retinoblastoma tumor suppressor modulates DNA repair and radio responsiveness |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we show that RB loss promotes sensitization to genotoxic stress through mechanisms distinct from cell cycle checkpoint control, and identify RB as a potent effector of the response to radiotherapy.
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| Overall design |
Transcriptome analysis was performed, validated, and mechanisms discerned and multiple mechanisms were interrogated including cell cycle, apoptosis, and DNA damage repair.
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| Contributor(s) |
Thangavel C, Boopathi E, Ciment S, Liu Y, Sharma A, McMahon SB, Mellert H, Addya S, Ertel A, Birbe R, Fortina PM, Dicker AP, Knudsen KE, Den RB |
| Citation(s) |
25165096 |
| Submission date |
Jun 20, 2014 |
| Last update date |
Mar 15, 2019 |
| Contact name |
Adam Ertel |
| Organization name |
Thomas Jefferson University
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| Department |
Cancer Biology
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| Lab |
BLSB 1009
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| Street address |
233 S 10TH ST
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| City |
PHILADELPHIA |
| State/province |
PA |
| ZIP/Postal code |
19107 |
| Country |
USA |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA253295 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58711_RAW.tar |
68.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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