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| Status |
Public on Jun 01, 2015 |
| Title |
Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques |
| Platform organism |
Homo sapiens |
| Sample organism |
Macaca mulatta |
| Experiment type |
Expression profiling by array
|
| Summary |
We studied the effect of alcohol admistration on the gene profiles of skeletal muscle of SIV-infected macaques. We found that alcohol-treated SIV-infected monkeys had altered gene patterns associated with ECM remodeling including TIMP-1, MMP2 and MMP9
In addition, hydroxyproline content and picrosirius staining reflected greatest collagen deposition in the alcohol-SIV muscle tissue.
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| Overall design |
Animals were infused intragastrically with alcohol or sucrose daily for three months prior to intravenous SIV inoculation with 10,000X the ID50SIV mac251 for about 13 months
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| Contributor(s) |
Dodd T, Simon L, LeCapitaine NJ, Zabaleta J, Mussell J, Berner P, Ford S, Dufour J, Bagby GJ, Nelson S, Molina PE |
| Citation(s) |
25421506 |
| Submission date |
Jul 07, 2014 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Patricia Molina |
| E-mail(s) |
pmolin@lsuhsc.edu
|
| Phone |
504-568-6171
|
| Organization name |
LSU health Sciences Center
|
| Department |
Physiology
|
| Street address |
1901 Perdido St.
|
| City |
New Orleans |
| State/province |
Louisiana |
| ZIP/Postal code |
70112 |
| Country |
USA |
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| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA254453 |
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