|
| Status |
Public on Oct 08, 2014 |
| Title |
BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Coordinated BCR-ABL1 kinase-dependent and -independent mechanisms convert p27 from a nuclear tumor suppressor to a cytoplasmic oncogene. Persistence of oncogenic p27 functions despite effective inhibition of BCR-ABL1 may contribute to resistance to tyrosine kinase inhibitors.
|
| |
|
| Overall design |
BCR-ABL1 induced p27 versus knockout, controlling with Empty vector p27 versus knock out
|
| |
|
| Contributor(s) |
Deininger M, Agarwal A |
| Citation(s) |
25293778 |
| Submission date |
Jul 07, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
David Ellison |
| Organization name |
Oregon Health and Science University
|
| Street address |
3181 SW Sam Jackson Park Rd CR145
|
| City |
Portland |
| State/province |
OR |
| ZIP/Postal code |
97239 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA254523 |
| SRA |
SRP044124 |
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