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| Status |
Public on Dec 01, 2014 |
| Title |
Expression data comparing TMNK-1 to HMEC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Liver sinusoidal endothelial cells (LSECs) are an endothelial subtype specific to the liver with unique functions when compared to other endothelial subtypes. We have demonstrated that supernatants from an immortalized LSEC line (TMNK-1) control HCV viral replication in vitro. Supernatants from a human microvascular endothelial cell line (HMEC) did not control viral replication suggesting this anti-viral effect is unique to LSECs.
We used microarray to analyze the transcriptional differences between these cell lines to further shed light on their differential effects on HCV replication in vitro
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| Overall design |
TMNK-1 cells or HMEC were cultured for 48h without stimulation; total RNA was then harvest to determine transcriptional differences.
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| Contributor(s) |
Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 26, 2014 |
| Last update date |
Mar 15, 2019 |
| Contact name |
Michael Edwards |
| E-mail(s) |
michael.edwards@ucdenver.edu
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| Phone |
303-724-6054
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| Organization name |
UC Denver
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| Department |
Pulmonary
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| Street address |
12700 East 19th Avenue, Box C272
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| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80045 |
| Country |
USA |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA259528 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE60776_RAW.tar |
45.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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