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| Status |
Public on Sep 21, 2016 |
| Title |
RRBS assessment of global methylation alterations alterations in Dnmt3aKO/FLT3-ITD leukemia |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Using RRBS we assessed global DNA methylation changes in two mouse models of oncogenic FLT3-driven leukemia in the presence and absence of Dnmt3a.
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| Overall design |
Mouse RRBS DNA methylation maps of Dnmt3aKO/FLT3-ITD leukemias, Dnmt3aKO/FLT3-ITD leukemias overexpressing Dnmt3a or GFP, FLT3-ITD leukemias, normal CD4+/CD8+ thymocytes, Dnmt3aKO thymocytes, heterozygous Dnmt3a/heterozygous Flt3-ITD knockin leukemias, and heterozygous Flt3-ITD knockin pre-leukemic bone marrow cells were obtained by sequencing on Illumina HiSeq 2000 or 2500.
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| Contributor(s) |
Rodriguez B, Li W, Goodell M |
| Citation(s) |
27300438 |
| Submission date |
Oct 01, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Margaret Goodell |
| Organization name |
Baylor College of Medicine
|
| Street address |
One Baylor Plaza, N1030
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE61971 |
Molecular profiling of mouse Dnmt3a/FLT3-ITD leukemia models |
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| Relations |
| BioProject |
PRJNA262829 |
| SRA |
SRP048580 |
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