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| Status |
Public on Jan 01, 2015 |
| Title |
Expression data from LNCaP prostate cancer cells treated with taxanes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Comparison of the new generation taxane cabazitaxel with docetaxel in prostate cancer cells
Cabazitaxel impacts distint molecular pathways as compared to docetaxel, which could underlie its efficacy after docetaxel treatment has failed in castration resistant prostate cancer patients
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| Overall design |
12 samples were analysed. A genome-wide expression array was performed on a GeneChip Human Gene 2.0ST Array (Affymetrix, 902112) with LNCaP cells infected with a control plasmid (MSCV-LMP), treated for 16h with 1nM cabazitaxel, docetaxel or vehicle (EtOH), in duplicates. The expression data were RMA normalized, and filtered to remove low-expressing genes. Differential gene expression with corresponding p-values (student’s ttest) was determined of drug-treated over control.
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 19, 2014 |
| Last update date |
Mar 15, 2019 |
| Contact name |
Karen Knudsen |
| Organization name |
Thomas Jefferson University - Kimmel Cancer Center
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| Street address |
233 S 10th St, BLSB 1008
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| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19107 |
| Country |
USA |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM1550559 |
LNCaP CTRL treated in charcoal dextran treated serum, replicate 1 |
| GSM1550560 |
LNCaP CTRL treated in charcoal dextran treated serum, replicate 2 |
| GSM1550561 |
LNCaP 16h cabazitaxel (1nM) treated in charcoal dextran treated serum, replicate 1 |
| GSM1550562 |
LNCaP 16h cabazitaxel (1nM) treated in charcoal dextran treated serum, replicate 2 |
| GSM1550563 |
LNCaP 16h docetaxel (1nM) treated in charcoal dextran treated serum, replicate 1 |
| GSM1550564 |
LNCaP 16h docetaxel (1nM) treated in charcoal dextran treated serum, replicate 2 |
| GSM1550565 |
LNCaP CTRL treated in full serum, replicate 1 |
| GSM1550566 |
LNCaP CTRL treated in full serum, replicate 2 |
| GSM1550567 |
LNCaP 16h cabazitaxel (1nM) treated in full serum, replicate 1 |
| GSM1550568 |
LNCaP 16h cabazitaxel (1nM) treated in full serum, replicate 2 |
| GSM1550569 |
LNCaP 16h docetaxel (1nM) treated in full serum, replicate 1 |
| GSM1550570 |
LNCaP 16h docetaxel (1nM) treated in full serum, replicate 2 |
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| This SubSeries is part of SuperSeries: |
| GSE63479 |
LNCaP and C4-2 prostate cancer cells treated with taxanes |
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| Relations |
| BioProject |
PRJNA268012 |
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