 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Dec 15, 2014 |
| Title |
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling.
|
| |
|
| Overall design |
Comparison of transcriptional profiles of native RNASEH2-deficient patient fibroblasts with wild type cells.
|
| |
|
| Contributor(s) |
Günther C, Kind B, Reijns M, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell K, Ramantani G, Bauernfeind A, Morris D, Graham DC, Bubeck D, Leitch A, Ralston S, Blackburn E, Gahr M, Witte T, Vyse T, Melchers I, Mangold E, Nöthen M, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs J, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme M, Jackson A, Lee-Kirsch MA |
| Citation(s) |
25500883 |
| Submission date |
Dec 01, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Min Ae Lee-Kirsch |
| E-mail(s) |
MinAe.Lee-Kirsch@uniklinikum-dresden.de
|
| Organization name |
TU Dresden
|
| Department |
Universitätsklinikum Carl Gustav Carus
|
| Lab |
Molekulare Pädiatrie
|
| Street address |
Fetscherstraße 74
|
| City |
Dresden |
| ZIP/Postal code |
01307 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA268979 |
| SRA |
SRP050397 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE63755_RPKM_RNASEH2_JCI_p156.txt.gz |
57 b |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...