|
| Status |
Public on Jul 27, 2015 |
| Title |
MicroRNA expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the thebiological risk factors associated with PCa disparities observed in AA and EA patients, we performed microRNA profiling using Agilent Human miRNA arrays to identify the differentially expressed microRNAs beween: 1) AA and EA PCa patients; 2) AA PCa vs. AA normal; and 3) EA PCa vs. EA normal.
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| Overall design |
54 prostate biopsy specimens (tumor and adjacent normal tissues) were collected from 14 African American and 13 European American prostate cancer patients. 54 RNA samples, purified from the collected biopy specimens using Qiagen miRNeasy kit, were process and applied to Agilent human miRNA arrays. Array data was normalized and analyzed using Agilent GeneSpring program.
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| Contributor(s) |
Wang B, Lee NH |
| Citation(s) |
26089375 |
| Submission date |
Dec 18, 2014 |
| Last update date |
Aug 06, 2015 |
| Contact name |
Bi-Dar Wang |
| E-mail(s) |
wangbi@gwu.edu
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| Phone |
202-994-3543
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| Fax |
202-994-2870
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| Organization name |
The George Washington University Medical Center
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| Department |
Pharmacology and Physiology
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| Street address |
2300 I street, NW
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| City |
Washington |
| State/province |
DC |
| ZIP/Postal code |
20037 |
| Country |
USA |
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| Platforms (1) |
| GPL8227 |
Agilent-019118 Human miRNA Microarray 2.0 G4470B (miRNA ID version) |
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| Samples (54)
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| This SubSeries is part of SuperSeries: |
| GSE64333 |
MicroRNA and Gene expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients |
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| Relations |
| BioProject |
PRJNA270803 |
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