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| Status |
Public on Sep 25, 2015 |
| Title |
Effect in MOLM-14 cells of 24hr cortistatin A treatment on gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML proliferation.
In this series, we examine the transcriptional effect on MOLM-14 cells of 24hrs exposure to CA.
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| Overall design |
MOLM-14 cells were treated in triplicate with either DMSO or CA for 24hrs. RNA was harvested and hybridized to microarrays to assess transcriptional changes.
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| Contributor(s) |
Pelish HE, Liau BB, Banka D, Armstrong SA, Lemieux ME, Shair MD |
| Citation(s) |
26416749 |
| Submission date |
Jan 15, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Matthew D. Shair |
| Organization name |
Harvard University
|
| Department |
Chemistry and Chemical Biology
|
| Lab |
Shair
|
| Street address |
12 Oxford Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE65161 |
Mediator kinase inhibition further activates super-enhancer-associated genes in AML |
|
| Relations |
| BioProject |
PRJNA273292 |
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