|
Status |
Public on Sep 25, 2015 |
Title |
Effect in MV4;11 cells of 3hr cortistatin A treatment on gene expression |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
|
Summary |
We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML proliferation. In this series, we examine the transcriptional effect on MV4;11 cells of 3hrs exposure to CA to identify immediate effects.
|
|
|
Overall design |
MV4;11 cells were treated in triplicate with either DMSO or CA for 3hrs. RNA was harvested and hybridized to microarrays to assess transcriptional changes.
|
|
|
Contributor(s) |
Pelish HE, Liau BB, Da Silva DH, Lemieux ME, Shair MD |
Citation(s) |
26416749 |
Submission date |
Jan 15, 2015 |
Last update date |
Mar 25, 2019 |
Contact name |
Matthew D. Shair |
Organization name |
Harvard University
|
Department |
Chemistry and Chemical Biology
|
Lab |
Shair
|
Street address |
12 Oxford Street
|
City |
Cambridge |
State/province |
MA |
ZIP/Postal code |
02138 |
Country |
USA |
|
|
Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
Samples (6)
|
|
This SubSeries is part of SuperSeries: |
GSE65161 |
Mediator kinase inhibition further activates super-enhancer-associated genes in AML |
|
Relations |
BioProject |
PRJNA273290 |