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| Status |
Public on Aug 27, 2015 |
| Title |
Nilotinib (Tasigna) in the Treatment of Early Diffuse Systemic Sclerosis: An Open-Label, Pilot Clinical Trial |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To assess the safety, efficacy, and molecular change associated with treatment of patients with early, diffuse cutaneous systemic sclerosis (dcSSc) with nilotinib (Tasigna™).
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| Overall design |
In this open-label pilot trial 6 adult patients with early dcSSc received nilotinib. Primary endpoints were safety and change in modified Rodnan Skin Score (MRSS) after 6 months. Lesional skin biopsies at baseline, 6 and 12 months of treatment were assessed by histopathology, immunohistochemistry, and DNA microarray.
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| Contributor(s) |
Gordon JK, Martyanov V, Magro C, Wildman H, Wood TA, Huang W, Crow MK, Whitfield ML, Spiera RF |
| Citation(s) |
26283632 |
| Submission date |
Jan 28, 2015 |
| Last update date |
Oct 11, 2016 |
| Contact name |
Tammara Wood |
| E-mail(s) |
tammara.a.wood@dartmouth.edu
|
| Organization name |
Dartmouth Medical School
|
| Department |
Biomedical Data Science
|
| Lab |
Whitfield Lab
|
| Street address |
WTRB 674
|
| City |
Lebanon |
| State/province |
NH |
| ZIP/Postal code |
03756 |
| Country |
USA |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA273886 |
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