|
| Status |
Public on May 01, 2016 |
| Title |
Dynamic regulation of the histone variant H1.0 contributes to intratumor epigenetic and functional heterogeneity [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Identification of genes regulated by the histone variant H1.0 by RNA-seq analysis of cell lines expressing inducible specific shRNAs.
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| |
|
| Overall design |
RNA-seq analysis of in vitro-transformed human skin fibroblasts expressing inducible shRNAs targeting H1.0. Two different cell lines expressing distinct shRNAs are analyzed. For ech cell line, uninduced cells (NT), cells induced with doxycycline for 16h (SHOT), cells induced with doxycycline for 14 days (DOX) and cells washed out of doxycycline for 4 days (washDOX) are compared.
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| |
|
| Contributor(s) |
Morales Torres C, Biran A, Henser-Brownhill T, Patel H, Hashahar A, Li Y, Nye E, Ben Hamo R, Matthews N, Misteli T, Meshorer E, Scaffidi P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 02, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Paola Scaffidi |
| E-mail(s) |
paola.scaffidi@crick.ac.uk
|
| Organization name |
Francis Crick Institute
|
| Lab |
Cancer Epigenetics Laboratory
|
| Street address |
1 Midland Road
|
| City |
London |
| ZIP/Postal code |
NW1 1AT |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (24)
|
| GSM1599193 |
sh52 hairpin SHOT biological replicate 1 |
| GSM1599194 |
sh52 hairpin SHOT biological replicate 2 |
| GSM1599195 |
sh52 hairpin SHOT biological replicate 3 |
| GSM1599196 |
sh52 hairpin DOX biological replicate 1 |
| GSM1599197 |
sh52 hairpin DOX biological replicate 2 |
| GSM1599198 |
sh52 hairpin DOX biological replicate 3 |
| GSM1599199 |
sh52 hairpin AFTER biological replicate 1 |
| GSM1599200 |
sh52 hairpin AFTER biological replicate 2 |
| GSM1599201 |
sh52 hairpin AFTER biological replicate 3 |
| GSM1599202 |
sh55 hairpin NT biological replicate 1 |
| GSM1599203 |
sh55 hairpin NT biological replicate 2 |
| GSM1599204 |
sh55 hairpin NT biological replicate 3 |
| GSM1599205 |
sh55 hairpin SHOT biological replicate 1 |
| GSM1599206 |
sh55 hairpin SHOT biological replicate 2 |
| GSM1599207 |
sh55 hairpin SHOT biological replicate 3 |
| GSM1599208 |
sh55 hairpin DOX biological replicate 1 |
| GSM1599209 |
sh55 hairpin DOX biological replicate 2 |
| GSM1599210 |
sh55 hairpin DOX biological replicate 3 |
| GSM1599211 |
sh55 hairpin AFTER biological replicate 1 |
| GSM1599212 |
sh55 hairpin AFTER biological replicate 2 |
| GSM1599213 |
sh55 hairpin AFTER biological replicate 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE65520 |
Dynamic regulation of the histone variant H1.0 contributes to intratumor epigenetic and functional heterogeneity |
|
| Relations |
| BioProject |
PRJNA274266 |
| SRA |
SRP053048 |
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