|
| Status |
Public on Feb 01, 2016 |
| Title |
Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and internal organs. We sought to assess the clinical and molecular effects associated with response to intravenous abatacept in patients with diffuse cutaneous systemic sclerosis (dcSSc).
|
| |
|
| Overall design |
Adult dcSSc patients were randomized in a 2:1 double-blinded fashion to receive abatacept or placebo over 24 weeks. Primary outcomes were safety and the change in modified Rodnan Skin Score (mRSS) at week 24 compared with baseline. Improvers were defined as patients with a decrease in mRSS of ≥30% post-treatment compared to baseline. Skin biopsies were obtained for differential gene expression and pathway enrichment analyses and intrinsic gene expression subset assignment.
|
| |
|
| Contributor(s) |
Chakravarty EF, Haddon DJ, Whitfield ML, Martyanov V, Jarrell JA, Chung L, Fiorentino D, Utz PJ |
| Citation(s) |
26071192 |
| Submission date |
Feb 26, 2015 |
| Last update date |
Oct 11, 2016 |
| Contact name |
Tammara Wood |
| E-mail(s) |
tammara.a.wood@dartmouth.edu
|
| Organization name |
Dartmouth Medical School
|
| Department |
Biomedical Data Science
|
| Lab |
Whitfield Lab
|
| Street address |
WTRB 674
|
| City |
Lebanon |
| State/province |
NH |
| ZIP/Postal code |
03756 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA276562 |
Less...
More...