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| Status |
Public on Dec 14, 2015 |
| Title |
H3K4me3 chromatin profiling in SUMOylation-competent and -deficient bone marrow derived dendritic cells unstimulated or stimulated with LPS |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Purpose: To determine H3K4me3 chromatin profile in UBC9WT and UBC9KO BMDC before and after LPS stimulation.
Methods: H3K4me3 chromatin profile was determined by sequencing UBC9 WT and UBC9 KO BMDC chromatin immunoprecipitated with antibody specific for H3K4me3.
Results: We show differential chromatin profile for H3K4me3 on the ifnb1 locus between UBC9 KO cells and UBC9 WT.
Conclusions: Loss of SUMOylation causes a deregulation of ifnb1 transcription activation mark.
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| Overall design |
A study of H3K4me3 chromatin profile in UBC9 WT and UBC9 KO Bone Marrow derived Dendritic Cells.
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| Contributor(s) |
Decque A, Joffre O, Magalhaes JG, Cossec J, Blecher-Gonen R, Seeler JS, Lapaquette P, Joubert P, Albert ML, Amit I, Amigorena S, Dejean A |
| Citation(s) |
26657003 |
| Submission date |
Feb 26, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Adrien Decque |
| Organization name |
Institut Pasteur
|
| Lab |
U993 Nuclear Organization and Oncogenesis
|
| Street address |
28 rue du Docteur Roux
|
| City |
Paris |
| ZIP/Postal code |
75013 |
| Country |
France |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE66339 |
Sumoylation coordinates repression of inflammatory and anti-viral gene programs during innate sensing |
|
| Relations |
| BioProject |
PRJNA276565 |
| SRA |
SRP055554 |
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