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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 20, 2007 |
| Title |
Aeromonas caviae infection, 24 hours |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus. Microarray profiling of murine small intestinal extracts, 24 hours after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (γ-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF-α) transcripts. A. caviae has always been considered an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests A. caviae colonizes murine intestinal tract and causes what has been described by others as a dysregulatory cytokine response leading to an irritable bowel-like syndrome. This response would explain why a number of diarrheal waterborne outbreaks have been attributed to A. caviae even though it lacks obvious enteropathogenic properties.
Keywords: Aeromonas caviae, infection, disease mechanism, TH1 resposne
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| Overall design |
Biological replicates (n=5), controls are uninfected mice, test replicates are infected with organism
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| Contributor(s) |
Vesper S, Rodgers M, Lye D, Stelma G, Donohue M |
| Citation(s) |
20130691 |
| Submission date |
Jan 17, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Samuel Hayes |
| E-mail(s) |
hayes.sam@epa.gov
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| Phone |
513-569-7514
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| Organization name |
United States Environmental Protection Agency
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| Department |
MS-387
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| Lab |
NRMRL/WSWRD
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| Street address |
26 W. Martin Luther King Dr.
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| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45268 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (9)
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| GSM155916 |
NRMRL test replicate01, EPA72 batch052005 430_2 chip |
| GSM155917 |
NRMRL test replicate02, EPA72 batch052005 430_2 chip |
| GSM155918 |
NRMRL test replicate03, EPA72, batch052005 430_2 chip |
| GSM155994 |
NRMRL test replicate04, EPA72 batch052005 430_2 chip |
| GSM155995 |
NRMRL test replicate05, EPA72 batch052005 430_2 chip |
| GSM155996 |
NRMRL control replicate01, uninfected batch052005 430_2 chip |
| GSM155997 |
NRMRL control replicate02, unifected batch052005 430_2 chip |
| GSM155998 |
NRMRL control replicate03, uninfected batch052005 430_2 chip |
| GSM155999 |
NRMRL control replicate04, uninfected batch052005 430_2 chip |
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| Relations |
| BioProject |
PRJNA98937 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE6765_RAW.tar |
36.7 Mb |
(http)(custom) |
TAR (of CEL) |
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