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| Status |
Public on Feb 09, 2017 |
| Title |
DLX3 alters transcriptomic profile of adhesion, cell cycle, and cell death in Squamous Cell Carcinoma Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Reinstatement of DLX3 into SCC13 cells upregulates genes involved with cell cycle exit, signaling, and adhesion whiles downregulates genes involved with cell death, proliferation, and movement.
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| Overall design |
We used RNA-sequencing data analysis to assess gene expression in SCC13 cells infected with Adeno-GFP or Adeno-DLX3 in order to understand the effects of DLX3 in a Squamous Cell Carcinoma Cell Line. We identified a specific subset of genes involved in regulation of cell cycle arrest and inhibition of apoptosis.
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| |
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| Contributor(s) |
Palazzo E, Kellett MD, Cataisson C, Gormley A, Bible PW, Pietroni V, Radoja N, Hwang J, Blumemberg M, Yuspa SH, Morasso M |
| Citation(s) |
26522723 |
| Submission date |
Apr 09, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Hong-wei Sun |
| Organization name |
NIAMS
|
| Department |
Office of Science & Technology
|
| Lab |
Biodata Mining & Discovery Section
|
| Street address |
9000 Rockville Pile
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE67714 |
DLX3-dependent p53 signaling network controls keratinocyte cell cycle and squamous tumor growth |
|
| Relations |
| BioProject |
PRJNA280746 |
| SRA |
SRP057020 |
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