|
| Status |
Public on Apr 15, 2015 |
| Title |
Histone architecture of stem-cell memory T cells reveals progressive remodeling of epigenetic landscape in antigen-experienced CD8 T cells |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We investigated the genomic landscape of histone modifications in antigen-experienced CD8+ T cells. Using a ChIP-Seq approach coupled with global gene expression profiling [GSE67825], we generated genome-wide histone H3 lysine 4 (H3K4me3) and H3 lysine 27 (H3K27me3) trimethylation maps in distinct subsets of CD8+ T cells - naïve, stem cell memory, central memory, and effector memory.
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| |
|
| Overall design |
To gain insight into how histone architecture is remodeled during the differentiation of activated T cells
|
| |
|
| Contributor(s) |
Crompton JG, Narayanan M |
| Citation(s) |
25914936 |
| Submission date |
Apr 14, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Nicholas Restifo |
| E-mail(s) |
restifo@nih.gov
|
| Organization name |
NIH
|
| Lab |
Surgery Branch, NCI
|
| Street address |
9000 Rockville pike
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA281104 |
| SRA |
SRP057167 |
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