|
| Status |
Public on Dec 31, 2015 |
| Title |
Differential gene expression in neuroblastoma cells after treatment with vehicle control, JQ1, panobinostat, or combination of JQ1 and panobinostat |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat induce synergistic anticancer effects
We analyzed whether JQ1 and panobinostat synergistically modulate gene expression
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| |
|
| Overall design |
Neuroblastoma SK-N-BE(2) cells were treated with vehicle control, 1 microM JQ1, 10 nM panobinostat, or combination of JQ1 and panobinostat for 6 hours, and subjected to differential gene expression studies with Affymetrix microarrays.
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| |
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| Contributor(s) |
Tao L |
| Citation(s) |
26733615 |
| Submission date |
May 08, 2015 |
| Last update date |
Mar 15, 2019 |
| Contact name |
Tao Liu |
| E-mail(s) |
tliu@ccia.unsw.edu.au
|
| Organization name |
Children's Cancer Institute Australia
|
| Street address |
Lowy Cancer Research Centre
|
| City |
Randwick |
| State/province |
NSW |
| ZIP/Postal code |
2031 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
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| Relations |
| BioProject |
PRJNA283437 |
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