|
| Status |
Public on Jul 14, 2015 |
| Title |
Recovery and analysis of nascent RNA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Nascent transcription profiles are shown for scaled megadomains and 100kb flanking regions before BRD4-NUT induction (0h) and at different time points (2h, 3h, 7h) following induction in 293T cells. Increase of the transcription from 0h to 7h after induction. Average level of transcriptional activity is reduced within the megadomains and their flanking regions following JQ1 treatment of TC-797 cells. Profile of nascent RNA-seq is shown for cells without JQ1 treatment, and for cells 1hr, 2.5hr and 4hr following JQ1 treatment.
|
| |
|
| Overall design |
Recovery and analysis of nascent RNA
|
| |
|
| Contributor(s) |
Kharchenko P, Wang X |
| Citation(s) |
26220994 |
| Submission date |
Jul 14, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Peter Kharchenko |
| Organization name |
Harvard Medical School
|
| Department |
DBMI
|
| Lab |
Kharchenko
|
| Street address |
10 Shattuck St.
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (14)
|
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| This SubSeries is part of SuperSeries: |
| GSE70868 |
The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains |
|
| Relations |
| BioProject |
PRJNA289739 |
| SRA |
SRP061033 |
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