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| Status |
Public on Apr 06, 2017 |
| Title |
Assessing the mechanism of action of BTK inhibitor, G7744 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: to investigate the method of action (MOA) of BTK small molecule inhibitor, G7744, in a pre-clinical mouse lupus model (NZB/W F1).
Hypothesis: BTK inhibition will affect B cell and myeloid cell pathways.
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| Overall design |
There are 5 mice per group. Sample groups: G1: Naive G2: Ad5 IFNa TD day 21 G3: Vehicle HPMC in citrate G4: BTK SMI G7744 100 mg/kg G5: SYK SMI G955 60 mg/kg G6: Anti ragweed IgG2a G7: mBR3 IgG2a G8: Cytoxan. Animals treated for 4 weeks. Samples: Spleen and kidney RNA from groups G1-G8.
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| |
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| Contributor(s) |
Townsend M, Ramamoorthi N, Hackney J |
| Citation(s) |
28405610 |
| Submission date |
Aug 26, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Mark McCreary |
| E-mail(s) |
mccrearm@gene.com
|
| Phone |
6502254332
|
| Organization name |
Genentech
|
| Department |
Bioinformatics
|
| Street address |
1 DNA Way, MS 93
|
| City |
South San Francisco |
| State/province |
California |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
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| Samples (114)
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| Relations |
| BioProject |
PRJNA293990 |
| SRA |
SRP062874 |
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