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| Status |
Public on May 18, 2007 |
| Title |
Gene expression in peripheral cells: effects of Foxp3 and PDE3B |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
This data set is comprised of all peripheral (pooled lymph nodes and spleen) T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells from mice treated with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressing retroviral vectors (after transfer into recipient mice).
Keywords: cell type comparison, response to growth factor, genetic modification
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| Overall design |
Detailed methods are presented in the manuscript and in the attached Supplementary Information. All RNA samples were derived from cells immediately after isolation from mice. Although this data set is comprised of 2 separate experiments (cells isolated from normal mice or IL-2 treated mice and cells transduced with retroviral vectors and passaged through recipient mice), the 10 expression arrays were normalized together to allow for cross comparison.
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| Contributor(s) |
Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY |
| Citation(s) |
17220874 |
| Submission date |
Mar 15, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Alexander Rudensky |
| Organization name |
University of Washington
|
| Department |
Immunology
|
| Street address |
1959 Pacific St
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98195 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (10)
|
| GSM154499 |
GFP- CD25- CD4+ cells from Foxp3(gfp/gfp) mice |
| GSM154500 |
GFP- CD25+ CD4+ cells from Foxp3(gfp/gfp) mice |
| GSM154501 |
GFP+ CD4+ cells from Foxp3(gfpko/wt) mice |
| GSM154502 |
GFP+ CD4+ cells from Foxp3(gfp/gfp) mice |
| GSM154725 |
GFP+ CD4+ cells from Foxp3(gfp/gfp) mice treated with IL-2 |
| GSM154726 |
GFP- CD25+ CD4+ cells from Foxp3(gfp/gfp) mice treated with IL-2 |
| GSM154727 |
GFP+ CD4+ cells from Foxp3(gfpko/wt) mice treated with IL-2 |
| GSM154730 |
GITR+ CD4+ cells from C57BL/6 mice transduced with empty MigR1 vector |
| GSM154733 |
GITR+ CD4+ cells from C57BL/6 mice transduced with MigR1-PDE3B |
| GSM154735 |
GITR+ CD4+ cells from C57BL/6 mice transduced with MigR1-PDE3B(H801A) |
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| This SubSeries is part of SuperSeries: |
| GSE7773 |
Foxp3-dependent programme of regulatory T-cell differentiation |
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| Relations |
| BioProject |
PRJNA105509 |
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