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| Status |
Public on Dec 02, 2015 |
| Title |
Gene expresssion profiles of cancer of the appendix |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Appendiceal cancer patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) often demonstrate an unpredictable variability in survival outcomes. Biomarkers predictive of CRS/HIPEC efficacy could better guide treatment decisions. In this study we hypothesized that variation in the transcriptional programming of appendiceal tumors might distinguish molecular subtypes with differential outcomes after CRS/HIPEC. The goal of this study was to investigate the potential of a prognostic gene signature to discriminate patients with favorable and unfavorable outcomes in a “discovery” set of patient (the original tumor series (n=24)), and confirm its prognostic value in a second “validation” series (the validation cohort (n=39)).
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| Overall design |
Total RNA isolated from 24 appendiceal tumors (the original tumor series) and 39 appendiceal tumors (the valdiation series) were profiled on Affymetrix U133A GeneChips and Affymetrix U219 GeneAtlas Array Strips, respectively.
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| Contributor(s) |
Miller LD, Chou JW, Levine EA |
| Citation(s) |
26821970 |
| Submission date |
Dec 01, 2015 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Lance David Miller |
| E-mail(s) |
ldmiller@wakehealth.edu
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| Phone |
3367166017
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| Organization name |
Wake Forest School of Medicine
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| Department |
Cancer Biology
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| Street address |
Medical Center Blvd
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| City |
Winston-Salem |
| State/province |
North Carolina |
| ZIP/Postal code |
27157 |
| Country |
USA |
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| Platforms (2) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
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| Samples (63)
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| GSM1958631 |
appendiceal cancer, validation series, 2001-41 |
| GSM1958632 |
appendiceal cancer, validation series, 2004-527 |
| GSM1958633 |
appendiceal cancer, validation series, 2004-650 |
| GSM1958634 |
appendiceal cancer, validation series, 2004-661 |
| GSM1958635 |
appendiceal cancer, validation series, 2004-751 |
| GSM1958636 |
appendiceal cancer, validation series, 2004-847 |
| GSM1958637 |
appendiceal cancer, validation series, 2005-128 |
| GSM1958638 |
appendiceal cancer, validation series, 2005-279 |
| GSM1958639 |
appendiceal cancer, validation series, 2005-295 |
| GSM1958640 |
appendiceal cancer, validation series, 2005-527 |
| GSM1958641 |
appendiceal cancer, validation series, 2005-584 |
| GSM1958642 |
appendiceal cancer, validation series, 2005-722 |
| GSM1958643 |
appendiceal cancer, validation series, 2005-859 |
| GSM1958644 |
appendiceal cancer, validation series, 2006-1067 |
| GSM1958645 |
appendiceal cancer, validation series, 2006-1183 |
| GSM1958646 |
appendiceal cancer, validation series, 2007-1116 |
| GSM1958647 |
appendiceal cancer, validation series, 2007-278 |
| GSM1958648 |
appendiceal cancer, validation series, 2007-30 |
| GSM1958649 |
appendiceal cancer, validation series, 2007-327 |
| GSM1958650 |
appendiceal cancer, validation series, 2007-352 |
| GSM1958651 |
appendiceal cancer, validation series, 2007-365 |
| GSM1958652 |
appendiceal cancer, validation series, 2007-473 |
| GSM1958653 |
appendiceal cancer, validation series, 2007-59 |
| GSM1958654 |
appendiceal cancer, validation series, 2007-866 |
| GSM1958655 |
appendiceal cancer, validation series, 2008-1171 |
| GSM1958656 |
appendiceal cancer, validation series, 2008-1181 |
| GSM1958657 |
appendiceal cancer, validation series, 2008-136 |
| GSM1958658 |
appendiceal cancer, validation series, 2008-1428 |
| GSM1958659 |
appendiceal cancer, validation series, 2008-1494 |
| GSM1958660 |
appendiceal cancer, validation series, 2008-1510 |
| GSM1958661 |
appendiceal cancer, validation series, 2008-365 |
| GSM1958662 |
appendiceal cancer, validation series, 2008-731 |
| GSM1958663 |
appendiceal cancer, validation series, 2008-756 |
| GSM1958664 |
appendiceal cancer, validation series, 2008-844 |
| GSM1958665 |
appendiceal cancer, validation series, 2008-866 |
| GSM1958666 |
appendiceal cancer, validation series, 2009-1061 |
| GSM1958667 |
appendiceal cancer, validation series, 2009-1526 |
| GSM1958668 |
appendiceal cancer, validation series, 2009-404 |
| GSM1958669 |
appendiceal cancer, validation series, 2011-1087 |
| GSM1958670 |
appendiceal cancer, original series, 2000-140 |
| GSM1958671 |
appendiceal cancer, original series, 2000-178 |
| GSM1958672 |
appendiceal cancer, original series, 2000-90 |
| GSM1958673 |
appendiceal cancer, original series, 2002-191 |
| GSM1958674 |
appendiceal cancer, original series, 2002-222 |
| GSM1958675 |
appendiceal cancer, original series, 2002-318 |
| GSM1958676 |
appendiceal cancer, original series, 2004-522 |
| GSM1958677 |
appendiceal cancer, original series, 2004-650 |
| GSM1958678 |
appendiceal cancer, original series, 2004-786 |
| GSM1958679 |
appendiceal cancer, original series, 2004-800 |
| GSM1958680 |
appendiceal cancer, original series, 2005-1129 |
| GSM1958681 |
appendiceal cancer, original series, 2005-427 |
| GSM1958682 |
appendiceal cancer, original series, 2005-685 |
| GSM1958683 |
appendiceal cancer, original series, 2005-760 |
| GSM1958684 |
appendiceal cancer, original series, 2006-1050 |
| GSM1958685 |
appendiceal cancer, original series, 2006-149 |
| GSM1958686 |
appendiceal cancer, original series, 2006-372 |
| GSM1958687 |
appendiceal cancer, original series, 2006-469 |
| GSM1958688 |
appendiceal cancer, original series, 2006-473 |
| GSM1958689 |
appendiceal cancer, original series, 2006-482 |
| GSM1958690 |
appendiceal cancer, original series, 2006-612 |
| GSM1958691 |
appendiceal cancer, original series, 2006-677 |
| GSM1958692 |
appendiceal cancer, original series, 2006-73 |
| GSM1958693 |
appendiceal cancer, original series, 2006-813 |
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| Relations |
| BioProject |
PRJNA304495 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE75535_RAW.tar |
125.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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