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| Status |
Public on Dec 31, 2017 |
| Title |
The role of PRMT5/WDR77 complex in promoting breast cancer oncogenesis [ChIP-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The PRMT5/WDR77 complex is known to regulate alternative splicing through the symmetric dimethylation of spliceosome proteins in the cytoplasm. Overexpression of this complex is observed in different types of cancer including breast cancer, where it shows increased nuclear accumulation.To understand the nuclear role and the chromatin binding properties of PRMT5 we performed genome-wide ChIP-Seq analysis in the breast cancer cell line MDA-MB-231.
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| Overall design |
Analysis of genome-wide binding of PRMT5 by chromatin immunoprecipitation followed by high throughput sequencing in MDA-MB-231 cells
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| Contributor(s) |
Rengasamy M, Zhang F, Zhang W, Walsh MJ |
| Citation(s) |
28977470 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 CA154809 |
Non-coding RNAs for Epigenetic Transcriptional Silencing in Prostate Cancer |
MOUNT SINAI SCHOOL OF MEDICINE |
Martin John Walsh, Zhou |
| R01 HL103967 |
Chromatin Dynamics of the CFTR locus |
MOUNT SINAI SCHOOL OF MEDICINE |
Martin John Walsh |
|
| Submission date |
Dec 07, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Martin J. Walsh |
| E-mail(s) |
martin.walsh@mssm.edu
|
| Organization name |
Mount Sinai School of Medicine
|
| Department |
Structural and Chemical Biology
|
| Street address |
One Gustave L. Levy Pl.
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE75743 |
The role of PRMT5/WDR77 complex in promoting breast cancer oncogenesis |
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| Relations |
| BioProject |
PRJNA305255 |
| SRA |
SRP067045 |
