|
| Status |
Public on Nov 01, 2007 |
| Title |
Expression in Kir6.1-deficient heart following LPS challenge |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
KATP opposes depolarization of cells in the heart, smooth muscle, and other tissues by permitting the efflux of potassium ions and this efflux is evidently required to prevent unopposed vasoconstriction and insufficiency of coronary artery blood flow triggered by one or more cytokines induced in response to LPS. The cytokine(s) involved must elicit a dysfunctional response in the Kir6.1-deficient environment, and to gain further insight into the effects of the mutation, we examined the transcriptional status of whole heart, isolated from normal C57BL/6J mice or KcnJ8Md/Md mice, before and after injection of 1 μg of LPS
Keywords: Time course, stress response, disease state analysis, genetic modification
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| |
|
| Overall design |
3 mice per genotype were injected with 0.5 ug LPS in PBS or with PBS alone and hearts were collected after 30 min or 3 h.
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| |
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| Contributor(s) |
Croker BA, Beutler BA |
| Citation(s) |
18026101 |
| Submission date |
Apr 24, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Yu Xia |
| E-mail(s) |
yuxia@scripps.edu
|
| Phone |
858-784-7364
|
| Organization name |
The Scripps Research Institute
|
| Department |
Genetics
|
| Lab |
Bruce Beutler
|
| Street address |
10550, N. Torrey Pines Rd.
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA100169 |
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