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| Status |
Public on Oct 21, 2008 |
| Title |
Gene expression changes in multiple brain regions of a mouse MPTP model of Parkinson's disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In Parkinson’s disease (PD), the progressive loss of substantia nigra dopamine cells has been associated with their vulnerability to oxidative stress, inflammation, and mitochondrial dysfunction. To identify multiple gene transcription alterations that may potentially underlie early stages of related degenerative processes in brain, we used the subcrhonic MPTP mouse model of PD and microarray analysis at 4 days post-MPTP when neurotoxic activity is maximal. Since PD results in gene changes throughout the brain, we assessed MPTP's effects in multiple regions: frontal cortex, striatum and midbrain.
Keywords: neurotoxic response
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| Overall design |
Mus musculus adults were randomly assigned to either MPTP or saline treatment groups. Brain regions of interest (frontal cortex, striatum and midbrain) were dissected from both groups for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Sforza DM, Hartenstein P, Lacan G, Melega WP, Toga AW |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 04, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Daniel M Sforza |
| E-mail(s) |
dsforza@gmu.edu
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| Organization name |
George Mason University
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| Department |
Computational and Data Sciences
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| Street address |
4400 University Drive
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| City |
Fairfax |
| State/province |
VA |
| ZIP/Postal code |
22030 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (18)
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| GSM187351 |
frontal cortex control, biological rep1 |
| GSM187352 |
frontal cortex control, biological rep2 |
| GSM187353 |
frontal cortex control, biological rep3 |
| GSM187354 |
striatum control, biological rep1 |
| GSM187355 |
striatum control, biological rep2 |
| GSM187356 |
striatum control, biological rep3 |
| GSM187357 |
midbrain control, biological rep1 |
| GSM187358 |
midbrain control, biological rep2 |
| GSM187359 |
midbrain control, biological rep3 |
| GSM187360 |
frontal cortex mptp, biological rep1 |
| GSM187361 |
frontal cortex mptp, biological rep2 |
| GSM187362 |
frontal cortex mptp, biological rep3 |
| GSM187363 |
striatum mptp, biological rep1 |
| GSM187364 |
striatum mptp, biological rep2 |
| GSM187365 |
striatum mptp, biological rep3 |
| GSM187366 |
midbrain mptp, biological rep1 |
| GSM187367 |
midbrain mptp, biological rep2 |
| GSM187368 |
midbrain mptp, biological rep3 |
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| Relations |
| BioProject |
PRJNA99841 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE7707_RAW.tar |
63.2 Mb |
(http)(custom) |
TAR (of CEL) |
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