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| Status |
Public on Sep 26, 2016 |
| Title |
Lnc-RNA expression pattern in ETV6/RUNX1-driven b-cell precursor acute lymphoblastic leukemia (BCP-ALL) |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Overwhelming evidence indicates that long non-coding RNAs have essential roles in tumorigenesis. Nevertheless, their expression and role in pediatric B-cell precursor acute lymphoblastic leukemia has not been extensively explored. Here, we conducted a comprehensive analysis of the long non-coding RNA transcriptome in ETV6/RUNX1 positive BCP-ALL, one of the most frequent subtypes of pediatric leukemia. An ETV6/RUNX1 expression signature was established, consisting of 596 lncRNAs (434 up and 162 down) using expression analysis of a series of primary patient samples. Subsequently, RNA sequencing from BCP-ALL cell lines and shRNA-mediated silencing of ETV6/RUNX1, illustrated that lnc-NKX2-3-1, lnc-TIMM21-5, lnc-ASTN1-1 and lnc-RTN4R-1 are bona fide ETV6/RUNX1 targets and could serve as novel biomarkers of this prevalent subtype of human leukemia.
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| |
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| Overall design |
Gene expression profiling of 64 BCP-ALL patient samples
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| |
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| Contributor(s) |
Ghazavi F, Van Loocke W, Van Vlierberghe P, De Moerloose B, Lammens T, Benoit Y, Speleman F |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 04, 2016 |
| Last update date |
Sep 26, 2016 |
| Contact name |
Farzaneh Ghazavi |
| E-mail(s) |
farzaneh.ghazavi@ugent.be
|
| Organization name |
Gent university hospital
|
| Department |
Center of medical genetics
|
| Street address |
De Pintelaan 185
|
| City |
Ghent |
| ZIP/Postal code |
9000 |
| Country |
Belgium |
| |
|
| Platforms (1) |
| GPL19197 |
Agilent-041648 CMGG Human V1.1 60k [Probe Name Version] |
|
| Samples (64)
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| This SubSeries is part of SuperSeries: |
| GSE79873 |
Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia |
|
| Relations |
| BioProject |
PRJNA317298 |
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