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| Status |
Public on Oct 01, 2020 |
| Title |
Gene expression analysis of serotonin transporter knock-out and wildtype rats during rat postnatal prefrontal cortex development |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To unravel the effect of increased extracellular serotonin levels on brain development, RNA-seq was performed in the medial prefrontal cortex of serotonin transporter knockout and wildtype rats at five time points from early life to adulthood (postnatal day (PND) 8, 14, 21, 35 and 70). Differential expression of protein-coding genes was analyzed and we demonstrate that a lack of functional 5-HTT especially affects gene expression in early postnatal life (PND8).
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| Overall design |
Comparison of gene expression between serotonin transporter wildtype and knockout rats at 5 different developmental time points (postnatal day 8, 14, 21, 35 and 70) in medial prefrontal cortex of Wistar rats. 5 samples per time point per genotype.
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| Contributor(s) |
Zhou J |
| Citation missing |
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| Submission date |
Apr 04, 2016 |
| Last update date |
Jun 14, 2022 |
| Contact name |
Jo Huiqing Zhou |
| E-mail(s) |
jo.zhou@radboudumc.nl
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| Organization name |
Radboud University
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| Street address |
Geert Grooteplein 26/18
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| City |
Nijmegen |
| ZIP/Postal code |
6525GA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
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| Samples (50)
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| Relations |
| BioProject |
PRJNA317356 |
| SRA |
SRP072848 |
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