|
| Status |
Public on Jun 01, 2016 |
| Title |
PWC dataset for genome-wide association study of modifiers of risk of canine degenerative myelopathy in dogs homozygous for SOD1 mutation |
| Organism |
Canis lupus familiaris |
| Experiment type |
SNP genotyping by SNP array
|
| Summary |
Degenerative myelopathy (DM) is a canine disease very similar to amyotrophic lateral sclerosis (ALS) in humans. We previously showed that DM is a promising model for ALS, as genome-wide association identified a mutation in SOD1, a known ALS gene. In this study, we identify a modifier gene, SP110, which strongly affects overall disease risk and age-of-onset in Pembroke Welsh corgis at risk of DM. Dissecting the complex genetics of this disease in a model organism may lead to new insights about risk and progression in both canine and human patients.
|
| |
|
| Overall design |
15 DM-affected and 31 unaffected PWC homozygous for SOD1 mutation genotyped using the Illumina CanineHD array (~170,000 SNPs genomewide)
|
| |
|
| Contributor(s) |
Ivansson EL, Megquier KJ, Lindblad-Toh K |
| Citation(s) |
27185954 |
| Submission date |
Apr 27, 2016 |
| Last update date |
May 25, 2020 |
| Contact name |
Kerstin Lindblad-Toh |
| Organization name |
Broad Institute
|
| Department |
Vertebrate Genome Biology
|
| Street address |
715 Main Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (46)
|
|
| Relations |
| BioProject |
PRJNA319840 |
Less...
More...