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| Status |
Public on May 18, 2016 |
| Title |
Effect of demeclocycline on brain tumor initiating cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We have determined that demeclocycline reduces the growth of brain tumor initiating cells (BTICs). Specifically, we sought to obtain insights into the mechanisms by which demeclocycline directly regulates BTIC growth. Analysis of the array data identified several genes that were altered with demeclocycline treatment that could regulate BTIC growth. The study provides the mechanistic basis for the regulation of BTIC growth with demeclocycline treatment.
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| |
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| Overall design |
We subjected 3 BTIC lines to microarray analyses to identify genes involved in the regulation of BTIC growth by demeclocycline. Three BTIC lines (BT012, BT025 and BT048) were treated with 10 µM demeclocycline for 6h. One (1) control and 1 treatment (demeclocycline treated) sample was generated from each BTIC line. Thus, a total of 6 RNA samples from 3 BTIC lines were obtained for microarray analysis.
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| |
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| Contributor(s) |
Yong VW, Li Y, Sarkar S |
| Citation(s) |
32153581 |
| Submission date |
May 17, 2016 |
| Last update date |
Mar 16, 2020 |
| Contact name |
Voon Wee Yong |
| E-mail(s) |
vyong@ucalgary.ca
|
| Phone |
4032208965
|
| Organization name |
University of Calgary
|
| Department |
Clinical Neurosciences
|
| Lab |
HMRB
|
| Street address |
3330 Hospital drive NW
|
| City |
Calgary |
| State/province |
Alberta |
| ZIP/Postal code |
T2N 4N1 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA321843 |
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