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| Status |
Public on Dec 15, 2016 |
| Title |
Gene expression signature of the T-ALL cell line LOUCY treated with 250nM (+)-JQ1 for 4h |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed the transcriptional consequences of the BET bromodomain inhibitor JQ1 in the T-ALL cell line LOUCY by microarray analysis. Short-term exposure to a low dose of JQ1 (4h, 250nM) provided insights in the genes whose expression was immediately affected by BET bromodomain inhibition.
Significantly downregulated genes upon short-term drug treatment included stem-cell associated genes and putative oncogenes such as BAALC, WT1, MN1, MEF2C, LMO1 and LMO2. Genes associated with the 500 highest ranked enhancer regions in LOUCY, were significantly enriched in genes downregulated after JQ1 treatment.
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| Overall design |
LOUCY cells were treated with 250nM (+)-JQ1 or DMSO for 4h. Three biological replicates of this treatment were performed.
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| Contributor(s) |
Peirs S, Van Vlierberghe P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 26, 2016 |
| Last update date |
Dec 16, 2016 |
| Contact name |
Sofie Peirs |
| E-mail(s) |
sofie.peirs@ugent.be
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| Organization name |
Ghent University
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| Street address |
De Pintelaan 185
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| City |
Gent |
| ZIP/Postal code |
9000 |
| Country |
Belgium |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE81918 |
Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia |
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| Relations |
| BioProject |
PRJNA323419 |
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