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Series GSE83591 Query DataSets for GSE83591
Status Public on Sep 05, 2017
Title Gene expression profiles of tumor epithelium and tumor-associated stroma of HER2+ breast tumors, plus normal epithelium and stroma from HER2+ and HER2- breast tumors
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Breast cancer is a heterogeneous disease. This heterogeneity can be observed at multiple levels, including gene expression, chromosomal aberrations, and disease pathology. A clear understanding of these differences is important since they impact upon treatment efficacy and clinical outcome. Many studies have shown that the tumor microenvironment also plays a critical role in cancer initiation and progression. Although genomic technologies have been used to gain a better understanding of the impact of gene expression heterogeneity on breast cancer outcome by identifying gene expression signatures associated with clinical outcome, histopathological breast cancer subtypes, and a variety of cancer-related pathways and processes, relatively little is known about the spectrum of heterogeneity in the tumor microenvironment.
 
Overall design 107 samples isolated by laser capture microdissection; in total, 40 samples of tumor epithelium, 39 samples of tumor stroma, 14 samples of normal epithelium and 14 samples of normal stroma; 2 samples possess biological replicates; each subjected to gene expression profiling in a common reference design using Agilent whole human genome oligonucleotide arrays.
 
Contributor(s) Park M
Citation(s) 28535374
Submission date Jun 21, 2016
Last update date Sep 05, 2017
Contact name Morag Park
E-mail(s) morag.park@mcgill.ca
Organization name McGill University
Department Goodman Cancer Research Centre
Street address 1160 Ave. des Pins O.
City Montreal
State/province Quebec
ZIP/Postal code H3A 1A3
Country Canada
 
Platforms (1)
GPL14550 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version)
Samples (109)
GSM2210454 park.mcgill.new.lcm 100_Tumor Epithelium
GSM2210455 park.mcgill.new.lcm 101_Tumor Epithelium
GSM2210456 park.mcgill.new.lcm 102_Tumor Epithelium
Relations
BioProject PRJNA326438

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83591_RAW.tar 647.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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