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| Status |
Public on Sep 01, 2016 |
| Title |
Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
It is unknown if gene expression profiles from primary RCC tumors differ from patient-matched metastatic tumors. Thus, we sought to identify differentially expressed genes between patient-matched primary and metastatic RCC tumors in order to understand the molecular mechanisms underlying the development of RCC metastases.
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| Overall design |
We compared gene expression profiles between patient-matched primary and metastatic RCC tumors. We employed Affymetrix U133 Plus2 microarrays to assess gene expression on 15 pairs of primary RCC (14 clear cell RCC, 1 papillary) tumors and patient-matched pulmonary metastases, across 54,675 probesets.
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| |
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| Contributor(s) |
Serie DJ, Eckel-Passow JE, Ho TH |
| Citation(s) |
27993815 |
| Submission date |
Aug 05, 2016 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Daniel Serie |
| E-mail(s) |
serie.daniel@mayo.edu
|
| Phone |
9049536451
|
| Organization name |
Mayo Clinic
|
| Street address |
4500 San Pablo Rd
|
| City |
Jacksonville |
| State/province |
Florida |
| ZIP/Postal code |
32224 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (31)
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| Relations |
| BioProject |
PRJNA337957 |
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